Compositions for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell. Other embodiments of the present invention relate to methods of heat treating nickel-base alloys, and in particular 718-type nickel-base alloys, to develop a desired microstructure that can impart thermally stable mechanical properties. Alternatively, the sealing element comprises an integral static seal part and the static seal part is formed by a radially projecting edge of the holding part of the sealing element that projects radially past the wall of the support body. The method then establishes a tunnel between the first PGW and a second PGW for the second distributed EPC.