The present invention provides novel techniques for controlling batch reaction processes. The method according to the invention comprises: a step of measuring at least one value of a primitive parameter Dsk representing said operating conditions, and a step of processing said parameter using a calculation unit that can execute a plurality of calculation operations. For example, a patient programmer may include both an internal antenna for RF telemetry with an implantable medical device and a display. In one embodiment, the service identifies pairs of works that are similar to each other by virtue of the relatively high frequency with which they co-occur on playlists or within play histories of users. The primary package and package insert are contained in an optional secondary package and the package insert does not contain a warning, a dosing instruction, or a dosing table specifically directed to patients suffering from mild, moderate or severe hepatic impairment, and preferably explicitly states that dosing adjustment is not required for mild or moderate hepatic impairment.