The invention provides methods for downmodulating an immune response comprising contacting immune cells from a subject with at least one agent that binds to at least one B7 molecule in combination with a Rapamycin compound. The drill bits comprise a bit body carrying at least one cutting element and having an infiltrated metal matrix. The thick support layer may be formed after the conducting posts have been formed, or the thick support layer is formed before forming the conducting posts in vias formed in the thick support layer. The specific textual content of each attribute field is identified. 1, at a frequency which is less than 1\u03c4. In this manner, this method suppresses access to the external memory, thereby reducing noise.