The present invention provides a method and apparatus for allowing a base station or base station controller to adjust transmissions to fixed location subscribers in closed-loop communication systems. The carrier element is preferably capable of being moved in translation or pivoted relative to the housing. According to the invention, the partial magnet arrangements may be displaced relative to each other. Both topical application and intradermal injection of this oligonucleotide to mice skin resulted in dark pigmentation of several hairs in localized area.