The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. Formed in a trench designed for a buried wiring of an interlayer insulation film are: a tantalum film having a film thickness of from 200 to 500 angstroms; and, a copper buried wiring having a film thickness of from 1. The inlet slot of the suction mechanism is situated axially in register solely with upstream portions of chords of the blades of the fan wheel at their radially outer ends. Such compositions and tubes are capable of facilitating rapid heat transfer in numerous heat transfer applications. In another approach, a hybrid histogram is created that includes a feature of frequency histograms and a feature of height-balanced histograms.