Provided herein are compounds having anti-proliferative effect. Increasing hydraulic cement reactivity increases early strength development and release of reactive calcium hydroxide, both of which enhance SCM replacement and 1-28 day strengths compared to blends of conventional Portland cement and one or more SCMs, such as coal ash, slag or natural pozzolan. A second secondary metal, is then thickly plated over the deposited first secondary metal without using photolithography. The assist dependent damping torque signal is then subtracted from the assist torque command signal. A first nose is formed at the first end, the first nose is adapted to fit in a screw hole in the bone plate such that the sleeve is rigidly fixed to the bone plate. Here, in a sampling phase before a hold phase, charges according an input signal V1p is stored in each of the capacitors, and charges according to an input signal V1p are stored in each of the capacitors.