In a signal processing device of an embodiment, an integration circuit accumulates a charge from a photodiode in an integrating capacitor element, and outputs a voltage value according to the amount of charge. A method of making the surfactant free coated fabric using a non-polar organic solvent is also disclosed. The present invention more specifically discloses an injectable dermal filler composition comprising hyaluronic acid and a white colorant. An epitaxial silicon layer is grown overlying the carbon-doped silicon layer to provide a starting wafer for the integrated circuit device fabrication. Also provided is a system for performing multiple solvent extractions utilizing several microfluidic chips or unit operations connected in series.