In some embodiments, estimating a duration of an idle period gap of a lower power state of a resource by exponentially smoothing successive idle period gaps. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the inventive metalloinsertor complexes. The hole is engaged with the toner replenishing container identifying portion of the mounting portion when the toner replenishing container is mounted on the mounting portion, is formed at a predetermined position on a front surface of the toner replenishing container in a mounting direction, and has a polygonal cross-section. The inverter-based low-pass filters filter harmonics of the clock signals with different phase angles. 50\u2003\u2003when f1 denotes a focal length of the first lens group, f2 denotes a focal length of the second lens group, R1a denotes a curvature radius in the first lens group nearest to the exit end face of the optical fiber, and R1b denotes a curvature radius of a lens surface in the first lens group nearest to the observation target.