An exercising bike includes a main frame and a rear frame adjustably connected with the main frame. Also provided are methods if using organisms having a known xenohormetically induced phenotype in a number of different applications, such as the identification of xenohormetic agents and the generation of chemical entities and foodstuffs under specific conditions of production governed by xenohormetic effects. Controlled bearing load reduction allows high speeds and a long service life of the bearings. The line card connector contacts are adapted to be selectively coupled to a backplane of a chassis.