An aqueous polishing composition having abrasive particles of a metal oxide has a pH that undergoes pH drift, because ions are provided by dissolution of the metal oxide, and the pH drift is minimized by providing the aqueous polishing composition with an equilibrium concentration of the ions at said pH. A rule engine, which executes the rules, may be called reactively when software accesses protected resources. The signals from each device can include unique IDs for identifying the device associated with the ID. The inputoutput module is configured to contain programmable logic for making the required connections between the module and the first and second devices. By the modification the presence of the protease, plasma hyaluronan binding protease, is decreased which minimizes the cleavage of Factor IX and enhances the yield of Factor IX in the purification process.