There is provided a glucose responsive membrane comprising a nanoporous support substrate and a coating of a glucose responsive hydrogel attached to a surface of the nanoporous substrate. Other embodiments are described and claimed. Also disclosed is a plasticmetal composite article prepared by the method of the present invention. Finally, methods are provided for treating transplantable neuronal stem cells by administering nilvadipine to the neuronal stem cells prior to transplantation in the central nervous system of an animal or human afflicted with a cerebral amyloidogenic disease, such as AD. A compression ratio is calculated for each of the identified files.