A hyaluronic acid derivative in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, and a production process thereof. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers. The antimicrobial moiety-containing endgroups include surface active moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. The transducer is enclosed in a pressure tight corrosion resistant housing and the housing is pressure sealed to the metal outer sheath. The analogs function unexpectedly well as universal bases.