A biosensor embodying the invention includes a sensing volume having an array of pores sized for immobilizing a first biological entity tending to bind to a second biological entity in such a manner as to change an index of refraction of the sensing volume. The categorizing of the images may be performed by a software failure analysis tool. A target machine notifies the server that the target machine has been powered-up. 0 \u03bcm, the content of the inorganic filler is 150 to 400% by mass based on the binder resin, and the protective layer comprises crosslinked polymethylmethacrylate particles.