Substituted 1-alkylamino-1H-indazoles for lowering intraocular pressure and treating glaucoma are disclosed. The film includes a gas permeable binder carrying oxygen sensitive material that changes in physical appearance at the location of an air leak. A latch has interengaging formations on the housing part and on the adjustment sleeve manually shiftable between a coupled position for rotationally locking the adjustment sleeve to the housing part and a decoupled position for rotation of the adjustment sleeve relative to the housing part. In an embodiment, the coupling beam structure includes two quarter-wavelength matched beams and an anchor located at a nodal point for coupling the two quarter-wavelength matched beams and ring resonator structures. The historical data may be analyzed to determine information regarding steps andor flow paths in the business process.