A spark plug wire having a first terminal and a second terminal wherein the first terminal is configured to operably couple to a distributor of a combustion engine and the second terminal operably couples to a spark plug. The column-shaped bodies have different heights andor different thicknesses. The applicator end of the device has both a back scratching mechanism and also a sponge to allow application of a portion of the volume of liquid. The switch is arranged to switch on at some point as the rectified AC voltage increases, once it has reached a non-zero value, thereby providing a current flow through the primary winding and hence through the secondary winding when the switch is switched off. The compounds according to the invention have immunomodulating andor cytokine release-inhibiting action and are therefore utilizable for the treatment of disorders which are connected with a disturbance of the immune system. The insulation layer within shallow trench isolation trench on the alignment is partly or completely removed.