A controller capable of preventing response delay and generation of vibrations attributable thereto during position control of a movable part of a machine having low rigidity. The toner is a toner in which; where, in displacement levels found in a micro-compression test in which a force is applied to a toner single particle at a loading rate of 9. For example, the light receiving element includes a first light receiving portion and a second light receiving portion which receive the light quantities of direct current part of light entering from the first and second light receiving portions. The closing and flow restriction member has at least a first area and a second area, which generate forces in opposite directions, when the component pressure is applied, wherein the areas are sized in such a way that the opposing forces substantially offset one another. Colored microparticles are constructed with specific electromagnetic absorption andor structural properties that facilitate changing andor removing tissue markings made using the microparticles by applying specific energy to the tissue marking site. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention.