Compounds of general formula, , and are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. The method also includes applying a correction table to the measured OSNR to generate a corrected OSNR using a controller, the correction table comprising a correction function to counteract an artifact in the measured OSNR. The length of the elastic resistance cord or flat band may be adjusted by means of a slip free, length quick adjustment device. A mixing valve in communication with the inlet recombines a remaining untreated portion of the water supply with the de-ionized portion. The invention also relates to methods of making these light transmitting filters. Audience reaction is configured to reflect a score obtained by the user.