The invention relates to proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. A light guide substrate includes a light introducing section and a light guide plate main body. A filler fills the sealed space. The catheter is manufactured with calibration markings, most likely equally spaced, and a radiopaque line along its length to enhance the maneuvering and the positioning thereof in the patient so that the distal tip of the catheter could be accurately positioned to the desired location of the patient’s trachealbronchial tree. If the water flows through the pathway, and the timer circuit reaches a predetermined manually set value, the valve closes the pathway, stopping the flow of water through the valve assembly. The reflector segments include interlocking means such as tabs and slots for attachment to other reflector segments.