Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. Specifically, the substrate tube is placed within a metal cladding tube made of platinum, gold, tantalum, tungsten, platinum-iridium, palladium, or nickel-titanium, preferably with an interference fit therebetween. The free running clock may be the source of other system clocks, such as a 32 KHz clock for system timing and a 13 MHz clock to facilitate audio playback, e. In one embodiment, a potential difference is applied across all gates to trigger Vbd, and then the fuse is broken to allow individual probing of breakdown of the alternate groups of gates.