The present invention relates to compounds of the general formula 1The compounds are useful in the treatment andor prevention of conditions mediated by clear receptors, in particular the Peroxisome Proliferator-Activated Receptors. The reference PLL locks onto the reference signal when the target signal is calibrated to be proportional to the reference signal. A probability of packet loss is based on the real-time feedback. The draft is transmitted to the server and on to the client.