Embodiments of the present invention relate to a messaging system for managing communications resources and are particularly suitable for providing a means for subscribers of a telecommunications network to continue participating in a communications service that would otherwise be ended due to the calling party having a low or zero balance. The method simulates the mixing and separation of contaminants that occur in an actual development system. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology. An epitaxial gate structure is formed within the trench by epitaxial regrowth. The two associated ground reference terminals are interconnected together so that electrically, they act as a single ground terminal having a width equal to the sum of the widths of the two connected ground reference terminals. The system and method of the invention can be implemented in hardware, or alternatively in a combination of hardware and software.