A method of radical-enhanced atomic layer deposition involves alternating exposure of a substrate to a first precursor gas and to radicals, such as monatomic oxygen radicals, generated from an oxygen-containing second precursor gas, while maintaining spatial or temporal separation of the radicals and the first precursor gas. The optical substrate can be a solid material, or a polymer, or even a wire mesh. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. The signal generation circuit generates a switching signal to control the switch. The present invention also relates to isolated genomic regions identified using the method of the present invention, one or more genes contained in the genomic regions and methods for detecting the presence of the one or more genes in an individual. It has a system for monitoring and commanding the ship, a system for navigating the ship, a system for coordinating weapons deployment, a system for handling the external and internal radio communications, a system for controlling and handling the information distribution, a system for power generation and distribution and a system for monitoring ship operations.