The subject matter relates to software application collaboration and, more particularly, collaboration between software applications via formular updates. To avoid interruptions in effective therapy, an implantable medical device may include a posture state module that detects the posture state of the patient and automatically adjusts therapy parameter values according to the detected posture state. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells. The device is used by an immersed moving body for independent determination of its absolute geographic coordinates. The migration may occur manually or automatically on a migratable services framework.