Compounds represented by Formula or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer. The gas hydrate is produced after infusion of liquid hydrate-forming material into water to be treated, which liquid hydrate-forming material can also be used to carry out all the refrigeration necessary to cool seawater to near the point of hydrate formation and to cool the porous restraint panels. 0 media mashup model that offers several key features including Near Real Time service continuity, control-proxy for a mobile-friendly web-surfing experience, finely-filtered content aggregation based on meta-data, context sensors and buddy blaster content sharingrecommendation.