A method of recording digital information signals on a removable rewritable disc like recording medium, the method comprising recording user data on a logical area of the disc and, prior to removal of the disc out of a recordingreproducing apparatus, finalizing the disc with a lead-in and lead-out area comprising predefined medium format data. The application check point may complete only after the system check point completes. The logic may have an operating mode and a sleep mode, with an inertial sensor providing a signal to cause the logic to switch from sleep mode to operating mode. The channel amplifying circuit adjusts the slew rate of a plurality of output voltage signals in response to the bias current control signal. The knuckle fitting has a largest cross-sectional area that is larger than the open cross-sectional area of the retaining region such that a portion of the knuckle fitting is retained within the bore. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.