The invention provides novel 1,2,4-thiadiazole derivatives useful for preventing or treating an \u03b1-synucleopathy such as Parkinson’s disease, as well as pharmaceutical compositions including them as biologically active ingredients, and methods for manufacturing them. More particularly, the invention teaches the practical utility of recrystallization of salt in solar salt pans using seawater itself as the dissolving medium. The method obtains a list of available channels from an electronic program guide service provider, and initializes the channel map based on the list of available channels. Multiple legs extend from the tubular body at a body end opposite to the flange. The alignment device is releasably secured to the golf grip and includes a feedback element.