A change controller application, process and system tracks modification to a configuration of a computerized device by receiving a change request indicating a requested change to an existing configuration of the computerized device and preparing a change notification message identifying the requested change to the existing configuration of the computerized device. Wireless transmissions from beacon devices are received at a plurality of receiver devices. The electrodes contain an electrochemically active material selected from an active carbon, a conductive polymer, and an insertion material suitable for inserting ions in its structure. The display portion is configured to move together with the drive member. An improved method of implanting radioactive seeds in a prostate gland is also disclosed. Also disclosed are methods for treating cancer and identifying compounds that modulate SIM2 expression.