Substituted pyrrolo-pyrazole derivatives of formula and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer. A master synchronization engine may synchronize to the difference unaware information repository and the difference aware information repository via connectors coupled to each information repository. Each stage of the combinatorial circuit includes sets of AND and XOR gates performing bitwise finite-field multiply and add on the operand bits, and the connections between registers and gates and between gates in the two stages are configured by multiplexer units responsive to RS and CRC instructions. The arrangement also includes a detection arrangement, which is coupled to a second plate of the measuring capacitor. The resin blend can be made by a number of methods. In the fitted state, the lid is clamped between the airbag guide and the edge region of the outlet opening for the airbag.