A system and method is provided of generating a map. The positioning an electromagnetic transmitter and an electromagnetic receiver step includes positioning them proximate to a side of the first ply. In another embodiment, the random group is selected by using predetermined patterns which are different among sub-cells, such as different means of constructing a dot. Direction andor location information associated with the user is ascertained, through messaging with the user or by antenna sensing. 7+50002\u2003\u2003formula D\xb7X\u22660. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer.