Route advertisement requests made by a customer are received at route provisioning center to effect either advertisement of a newly provisioned route or withdrawal of an existing route. The apparatus also calculates an actual intake air amount based on an actual throttle opening at the end of the previous suction stroke, and calculates an actual necessary fuel amount based on the actual intake air amount. , Y2 is hydrogen, an alkyl, cyano, \u2014C\u2550NR4, or a pharmaceutically acceptable salt thereof, or a non-toxic ester thereof, which has an excellent antibacterial activity against Gram-positive bacteria, especially against MRSA and MRCNS.