A detachable insulation wire-pressing element of a stapling device is disclosed. The compounds of the formula I are inhibitors of the sodium-calcium exchanger, especially of the sodium-calcium exchanger of subtype 1, and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. In response to the router advertisement message, the wireless communication device generates an acknowledgement message having a header extension that includes the location information.