The present invention relates to compounds of formula :in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The dimming controller is coupled to the input power signal and is further configured to determine a required dimming level based on the input power signal and to adjust the amount of DC lamp current such that the amount of light produced by the LED lamp corresponds to the determined required dimming level. A fund management information system determines a yield for each investor based on the shares of the fund purchased by the investor and the fixed-income securities held by the fund at the time that the shares were purchased.