The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. The drilling system has a second fluid pressure gradient lower than the first fluid pressure gradient in an annular space between the drillstring and the wellbore from a selected depth in the wellbore to the earth’s surface. The gateway device forwards an identification of the file to a remote datacenter in parallel with forwarding the data packets to the client machine.