The agent for the prevention andor treatment of Hand-Foot Syndrome comprising a compound with anticholinergic activity can be provided. A threaded stud is secured to a cap which includes a receptacle on a rear surface, complimentary to the head of the stud, and a display pocket on a forward or outer surface for receiving the medallion or coin. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. which can be received in the receiving chamber 11. The output signals are synthesized to produce a synthesized signal having a lower average voltage and current value, thus reducing power consumption of the signal amplifying device. This evaluation information is then incorporated into design rules in order to improve yield.