An optical cross-connect switch comprises a base, a flap and one or more electrically conductive landing pads connected to the flap. For example, process embodiments are disclosed in which wafer-scale as well as die-scale thermocompression bonding is utilized to encapsulate MEMS andor to provide electrical interconnections with MEMS. This diameter difference permits a longer, controllable stroke to dispense micro-liters of fluid accurately. The system can be portable and can be mounted on a vehicle for collection and treatment at various sites. Following this analysis, the objects are clustered into groups of warm or cold objects, and any links from warm clusters to cold clusters are determined. The method comprises detecting antibodies in serum, to a combination of transglutaminase and a substrate therefor.