Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ electrical field stimulation of the cells in order to manipulate the openclose state transition of the voltage-gated ion channels. The variable gain capability is achieved by replacing differential pair amplifiers having an input signal with less attenuation with one having an input signal that is more attenuated. Said thermal disconnector comprises at least one fuse element extending between a first and second conducting radial wall of an arc extinguishing chamber, said arc extinguishing chamber comprising at least one conducting separator. The first end of the second section is connected at an angle to the first end of the first section. The first direction has an angle about 1 degree to about 53 degrees to the second direction. A new encoder information record is built.