The invention is directed to techniques for providing an audibly controlled interface for a user of a limited audio-based communication device, for example, a telephony device such as a desktop telephone or a cellular telephone. Two oscillation systems which oscillate in opposite phases with respect to the fundamental wave of oscillation are formed to generate an even-order harmonic of the fundamental wave. Also described are methods of regulating pressure downstream from a fluid source using such fuses or breakers. The expandable engagement wall defines a passage, and the fastener extends through aligned openings in the first member and the head portion of the connector member, into the passage defined by the expandable engagement wall of the second member. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.