A system that calibrates timing relationships between signals involved in performing write operations is described. The method includes the steps of: coiling a tubular; accommodating the tubular in a deployment unit such that at least a portion of the coiled tubular is biased radially outwardly against the deployment unit; and deploying the tubular from the deployment unit along the predetermined path. There is also a keyboard controller for sensing use of one or more of the plurality of alphanumeric keys and passing of keyboard scan code to the host computer. By supporting the reaction vessel and fluid conduit in a common block, a single thermoelectric device and controller can be used to simultaneously control the respective temperatures of multiple fluid reagents andor gases, as well as one or more reaction vessels, thereby reducing the power requirements of the thermal control system. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.