The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyridine moiety which inhibit the activity of Akt, a serinethreonine protein kinase. The counter is incremented using a method that minimizes bit transitions from 1 to 0. By the driving element 22, the vacuum grid 19 and the curved pad 20 become close to each other in a substantially vacuum chamber. The method includes generating a payment authorization identifying the payee institution, the payee account, and an amount of the payment and transmitting the payment authorization to the payor institution. The microfluidic channels have been found to be particularly useful when formed in a self aligned process and used to interconnect a series of thin film transistor devices. The amplifier is a differential type, which outputs either a positive voltage or a zero voltage depending upon the majority of the inputs.