The present invention provides compounds of formula or which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. The skewing of the burnishing head relative to the diameter perpendicular to a sweeping direction provides improved wiping action that catches loose particles and surface contamination, as well as performing aggressive asperity cutting and surface conditioning, while preventing particles from being embedded into a disc surface. 5 micron to about 3-4 microns in diameter. The method further includes providing the bootable image of the network monitor to a requester, and then receiving a fixed IP address of the network monitor from a computing device on the customer network that is designated to host the network monitor. Due to the nature of the E-DCH transmission in the uplink in the Cell_FACH state and the fact that a wireless transmitreceive unit might set up and release the E-DCH resources more frequently, methods to deal with the TSN numbering are described.