In a sheet conveyance system in which a plurality of apparatuses each including a communication unit with a plurality of communication channels are connected, and a sheet is conveyed between the apparatuses, each of the plurality of communication channels can be switched between a transmission mode and a reception mode. The workpiece is oxidized in a soaking bath containing an aqueous solution comprised of a hydroxide and of a nitrate. An audio alarm is located within the housing and is actuated when the integrity of the sense loop is compromised. The loop filter is also configured to produce a set of phase adjustment signals based on the set of skew detection signals. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs of about 5.