A two-layered fenestrated vascular graft is provided for repair of diseased, damaged or aneurismal blood vessels. The transducer includes a device layer sensor means located on the substrate for measuring a parameter associated with the environment. The data acquisition component is communicatively connected to a sensor configured to acquire real-time data output from the electrical system. In order to achieve as high a sealing force as possible between the tubular bag and the adapter, a special seal is proposed. The resulting device has generally improved performance characteristics in terms of GMR ratio and junction resistance. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry.