The present invention provides methods and compositions for treating cyst formation in PKD1-associated epithelial cells. The flange extends radially outward from the axis and has a mating surface. The mobility of the stationary phase particles enables rapid mixing and equilibration with a sample solution during agitation. A resulting setID is assigned to the incoming fetch instruction based on the identified setIDs, wherein the resulting setID assigned is a setID not currently in use by the outstanding valid fetch entries.