Provided is an image diagnostic device with which the start and end of the in-flow of a contrast medium are automatically assessed. In an embodiment, the deployable template structure includes sections for virtual machines deployable, filters, and component configuration settings. The presence, abundance and extent of histological features and structural motifs comprising tumor-associated collagen signatures may be directly and accurately correlated with the onset and progression of cancer, such as breast cancer. A sensor senses a breach of integrity of the matrix. The jaws, in use, are movable to the open configuration to permit insertion of a cable through the aperture in the housing and, on release, are caused to move by the biasing means towards the closed configuration to clamp the cable therebetween.