A number of thalidomide metabolites having superior anti-angiogenic properties have now been isolated and identified. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free andor reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. Resonance is perceived by the hearing impaired individual as a buzzing or other abnormal noise, alerting the individual to the alarm condition. The controller compares the signals from the at least one pressure sensor to parameters generated by testing the working apparatus.