The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds. Methods of the present invention utilize a relatively low molecular weight polymer, multiple injection points, mold compression, andor a heated substrate in order to facilitate the injection of polymer into the relatively narrow space between glazing substrates that is typically found in safety glazings. A global hard mask layer is formed over the HKMG, the conductive feature and the first dielectric layer. Flow through the status chamber is from the outer lateral wall toward its central axis, whereby oily contaminants in the flow collect selectively at the outer portions of the filtration media which are highly visible to an observer. These methods and compositions utilize the hypodermis-targeted release from bioadhesive oral films, pastes or patches applied to oral mucosa or teeth for the purpose of improving the appearance or health of the lips and facial skin.