The invention provides methods of evaluating a treatment for its effect on skin. The method may also include identifying a target web document for each link in the set of links and determining a parental-control rating for each link in the set of links based on the target web document. The protein may alternatively comprise an altered antigen-binding portion where at least one of the peptide sequences is an altered sequence, an altered sequence being a sequence of FIG. A second textile may optionally be bonded to the adhesive opposing the first textile to form a multi-layered article. The image forming apparatus includes a pattern generator for generating a toner pattern, a pattern detection sensor for detecting the toner pattern formed on the intermediate transfer belt, a pattern density decider for determining the density of the toner pattern that makes the amount of light received by the sensor in detection of the toner pattern equal to or less than a predetermined value. This life path constant indicates the maximum acceptable state of wear of the tool for the machining of the workpiece.