An optical transmission device has an optical amplifier, first and second control signal reception units and a transmission unit. Methods for selecting agents which inhibit mutant SH3BP2 expression, as well as diagnostic and therapeutic methods which utilize the mutant SH3BP2 molecules for diagnosing and treating disorders of bone homeostasis, also are provided. Plants are resistant to Clematis wilt. A measure of the difference between each set of predicted values and the set of actual values is determined and, based thereon, a most likely configuration state is identified. The compounds are useful for the treatment andor prevention of diseases which are associated with the modulation of H3 receptors such as, for example, diabetes mellitus. In addition, a method using a quiz to determine if a user is human or an automated respondent is provided.