The invention relates to microscale cell handling apparatus which exhibit bulk fluid flow properties superior to prior art microscale cell handling devices. The driving mechanism includes a pair of lever members each having a force applying portion through which a force is applied to the slide plate and the force applying portion is disposed at substantially a central portion on a side portion of the slide plate in the slide plate moving direction. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation andor product isolation. The navigation path can also be defined by virtual simulation. Upon determining that the information is not proper, the apparatus issues a corresponding warning.