An infusion system that includes a controller device and a communication system to provide for two-way communication between the controller device and an infusion device that controls delivery of fluids to a user’s body. In an aspect, the housing is formed on the side of a board insertion opening with a recessed portion for conducting the board. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The unetched portion of the substrate makes a rim to support the sensing areas. The polarization impedance can be controlled by varying the asymmetrical alternating current.